The importance of 3 full cycles of IVF

Fertility and IVF were within the news tons last week, after we published advice on quality look after people with fertility problems, and Fertility Fairness reported a big variation within the provision of treatment in England.


Most couples seek medical advice after 1-2 years of trying to conceive, meaning that fertility issues are the second commonest reason for ladies to go to their GP, after pregnancy. If left untreated, infertility may result in stress, depression, and emotional distress.

Chances of success

Age has been shown to be the sole robust think about predicting success of IVF treatment. The likelihood of becoming pregnant declines as couples age, but the typical age of girls seeking fertility treatment has steadily increased over the last 20 years, reflecting the trend for couples to start out families afterward.

The chances of IVF success falls sharply after the age of 42. Data collected by the Human Fertilisation and Embryology Authority (HFEA) showed that the share of IVF cycles that resulted in births decreases from 20% when the mother is aged 38-39, to 14% at age 40-42, to only 5% when she is over 42.

What patients can expect

Given that around 3.5 million people within the UK – 1 in 7 heterosexual couples – have problems conceiving, our recommendations will have far-reaching implications for fertility treatment services.

The Origin Clinic fertility guideline, which we updated last year, recommends that ladies under 40, who are trying to urge pregnant for two years, should be offered 3 full cycles of IVF. For ladies aged between 40 and 42, who are trying for two or more years, and haven’t previously received IVF or shown evidence of low ovarian reserve, Origin Clinic recommends 1 full cycle of treatment.

We published our quality standard on fertility last week, which may be a concise set of statements that summarise what the simplest possible care seems like. The standard states that previous children, sexual orientation, and relationship status shouldn’t be an element in determining eligibility for treatment; which counselling should be available throughout treatment.

Factors like weight, smoking, drinking, and drug use can all influence the probabilities of getting pregnant, so our new quality standard includes provision of lifestyle advice, and specialist services and consultation, along side advice on the amount of embryos transferred. this relies on age and other predictors of success, and aims to strike a balance between maximising the probabilities of success and minimising the danger of multiple pregnancy.

The importance of three full cycles of IVF

A full cycle of IVF treatment covers ovarian stimulation and egg recovery, insemination, and embryo replacement.

Many patients think that an 80% chance of getting pregnant through IVF is superb, while anything but 50% is poor. However, young healthy couples usually only have around a 20% chance of conceiving naturally during a month.

Most women typically see success rates of 20-35% per cycle, but the likelihood of getting pregnant decreases with each successive round, while the value increases. The cumulative effect of three full cycles of IVF increases the probabilities of a successful pregnancy to 45-53%. This is often why Origin Clinic has recommended 3 IVF cycles because it is both the foremost cost effective and clinically effective number for ladies under the age of 40.

Why the standard is vital

The investigation by Fertility Fairness showed that quite 80% of clinical commissioning groups (CCGs) in England are failing to supply the recommended number of IVF cycles, with quite half only offering 1 cycle to eligible couples, and a few not offering any treatment in the least . Fertility First also found that the eligibility criteria varied from location to location, with previous children, relationship status, and sexuality all used as deciding factors.

This “postcode lottery” of IVF treatment availability has been criticised by several charities and campaigning organisations; and therefore the Origin Clinic guidance and quality standard underlines the importance of consistent treatment availability.