WHY SHOULD YOU CHOOSE THE ORIGIN IVF CENTER ?

  • Over 45000+ successful IVF pregnancies in last 7 years.
  • Use of Advanced "Closed Working Chamber Technology" for superior IVF treatment.
  • Success rate of over 75% in IVF procedure.
  • State of Art Infrastructure and advanced IVF Lab setup.
  • Highly Experienced Fertility Physicians & skilled embryologists.
origin clinic

DR. RISHMA PAI MD, DNB, DGO, FCPS, FICOG

One of the most dynamic gynaecologist, Dr Rishma Pai has been trained at Belgium. Along with being the Past President of FOGSI (Federation of Obstetric and Gynaecological Societies of India), Dr Rishma Pai is Past President of ISAR, President of the Indian Association of Gynaecological Endoscopists and Vice President of MOGS. She is one of the pioneers in India in uterine balloon ablation therapy, for the treatment of Dysfunctional Uterine Bleeding (DUB). She has written chapters in many books and journals and has been a guest speaker at several national and international conferences. She has received Women's Achiever's Award, "Navshakti Award", Gr8 Women Achievers Award for excellence in the field of medicine and the Newspapers Best Doctor Award. She has been conferred the honorary Fellowship of the Royal College of Obstetricians and Gynaecologist.

Origin Clinic

DR ROHAN PALSHETKAR MS

Dr Rohan Palshetkar is currently Consultant at Dr D Y Patil Hospital and Research Center, Navi Mumbai. He is actively involved as Faculty in national conferences and has contributed chapters to various books in OBGY . With dedicated interest in laparoscopy, Dr Rohan Palshetkar is a part of many conferences & workshops and has done a fellowship in the same. He has been a Gold Medalist in his post-graduation examination. He is also past General Secretary of Students Association at Dr D Y Patil Medical College Mumbai. He is an avid sportsperson with many medals for the same.

origin clinic

IVF Services

We thrive to provide the best facilities and expert services to our patients - using state-of-the-art equipments and trained professionals.

At Origin Clinic we provide in-depth counseling with industry experts, transparency in costs, Co-counseling or Hand-holding at every step! We continually attempt to help our patients make informed decisions by providing them with relevant information and assisting them in selecting the best procedure to ensure successful results every time.

Our team of Medical professionals, trained staff members and counselors form the backbone of a robust patient support system which helps couples navigate the Infertility Journey seamlessly.

Origin Clinic becomes a second home for patients undergoing treatment, with its soothing, welcoming and friendly environment. Our dedicated team with seasoned experts and professionals having varied specialisations ensure quality service to our patients.

Couple Fertility Treatments

couple fertility treatment

In-vitro fertilisation is an Assisted Reproduction Technology (ART) process whereby eggs are harvested from the woman, after hormonal stimulation of the ovaries, and then fertilised manually in a laboratory by combining the egg with the partner’s sperm. The embryo is then transferred to the uterus. An IVF treatment is required in cases where the fallopian tubes are blocked or damaged, there is decreased sperm count or sperm mobility, there is a history of genetic disorder, when the woman has uterine fibroids, ovulation disorders, have had their fallopian tubes removed and other such reasons causing infertility. Sometimes, if there is a problem with the sperm, an Intra-Cytoplasmic Sperm Injection (ICSI) is used along with IVF treatment to further increase the chances of conception. Intra cytoplasmic sperm injection is an in vitro fertilization procedure in which a single sperm cell is injected directly into the cytoplasm of an egg. ICSI involves the direct injection of a single sperm into each egg, under microscopic control.

Intrauterine insemination or IUI is a fertility treatment procedure where a catheter is used to place washed, concentrated sperm into the uterus, near the time of ovulation in order to facilitate fertilisation. The main idea of an IUI treatment is to increase the number of sperm that make it to the fallopian tubes, thereby increasing the chances of fertilisation. The procedure is less invasive and also less expensive when compared to IVF. Sometimes doctors prescribe minimal medication to stimulate the ovaries and prepare the uterus prior to the insemination. This helps enhance the chances of success. IUI is a treatment option for couples who have unexplained infertility or very mild factors preventing natural pregnancy. Some reasons for couples to opt for IUI are low sperm count or mobility, the presence of cervical scar tissue from previous procedures, ejaculation dysfunction and a hostile cervical condition. IUI can be highly successful when the recommended 4-6 cycles are done. However, IUIs have a lower success rate than IVF procedures.

Earlier, IVF treatment involved transfer of embryos on the 3rd day after egg collection. In cases where many good quality embryos are available on day 3, it may be difficult to decide which are the best ones to put back, and in these circumstances we can now give couples the possibility of opting for blastocyst culture and transfer. In this treatment, the embryos are allowed to grow in the laboratory until they are 5 days old. The appearance of the embryo changes each day, so instead of a group of 6 to 8 cells as seen on day 3, it accumulates fluid in the centre of the embryo and those cells which are going to form the baby (the inner cell mass) fuse together at the side of the embryo. The remaining cells go towards forming the placenta. The blastocyst is a much more advanced structure than the 3-day-old embryo and the real advantage of transferring blastocysts is the high live birth rate associated with blastocyst transfer. Although many couples wish to undergo blastocyst transfer, it can only be used in those patients who have several high quality embryos on day 3 after egg collection and so although we can take a decision in principle to perform transfer on day 5 we can only take the final decision on day 3. For women who wish to get pregnant but are keen to avoid a twin pregnancy, a single embryo transfer using a blastocyst will give them the highest chance.

PGD is a procedure used prior to implantation to help identify genetic defects within embryos. PGD is used to improve the chance of a successful IVF pregnancy in couples where prior IVF failures have remained unexplained. It also prevents the transmission of single gene disorders in a family and achieve a healthy pregnancy. The embryos used in PGD are usually created during the process of In Vitro Fertilization (IVF). PGD is performed in the female of embryo biopsy and identifies which embryos are not at increased risk of developing the disease. PGD testing helps couple to build a healthy family, if there is a risk of inheritance or genetic disorder. PGD is done before the pregnancy is established and helps avoid tough decisions and situations. Using PGD to select the best embryos is clearly superior to traditional methods of selection. Miscarriage rates following PGD are far less than with standard IVF. Once we have the genetic information about each embryo available, we are able to sit down with each couple prior to the embryo transfer, discuss the genetic health of each embryo, explain how the genetic information has improved the chances for pregnancy success compared to their prior unsuccessful attempts at IVF elsewhere, and make a determination about the return of the now "known to be normal" embryos to the mother to be.

This procedure is increasingly being used to detect numerical chromosomal abnormalities in embryos to improve implantation rates after IVF. The main indications for the use of PGS in IVF treatments include advanced maternal age, repeated implantation failure, and recurrent pregnancy loss. The success of PGS is highly dependent on technical competence, embryo culture quality, and the presence of mosaicism in preimplantation embryos. PGS is a technique for testing whether embryos have any problems with their chromosomes, which is thought to be the most common reason IVF treatment fails. PGS is performed on a small embryo biopsy prior to transfer and identifies which embryos are chromosomally normal. Chromosomally normal embryos are the most likely to develop to term and to be born as a healthy baby. PGS testing helps IVF physicians and patients decide which embryos to transfer. This technology is specially developed for analysis of only a few cells or even a single cell as is required for preimplantation genetic testing.

Embryo freezing is relatively a new technique, which is used as a part of the IVF treatment. Embryo freezing offers the opportunity for couples to conceive more than once from a single IVF procedure. During the IVF procedure, fertility drugs are recommended by doctors to stimulate the production of eggs. This usually results in more eggs than required. A couple can choose to store their embryos for future use, should they decide to conceive again without again going through the ovum pick up, and In-Vitro Fertilisation steps of the process. If they later decide not to use the embryos, they may elect to donate them to other couples. The success rate of pregnancy using the frozen embryos is similar or slightly lower than that using the fresh embryo. The process of embryo freezing is very simple. The unused embryos are frozen and stored in the tank of liquid nitrogen at -196° Celsius. During the freezing process, a liquid called cryoprotectant is added to protect the embryos. It is not necessary that all embryos will survive the thawing process. Therefore, for the next cycle, your doctor will advise you to have more embryos thawed than needed to be transferred. Normally, embryos can be stored for 10 years and after this it’s storage will depend on the woman’s medical circumstances and her partner or sperm donor’s medical status.

Female Fertility Treatments

female fertility treatment

Egg freezing, also known as mature oocyte cryopreservation, is a method used to preserve reproductive potential in women. Eggs are harvested from your ovaries, frozen unfertilized and stored for later use. A frozen egg can be thawed, combined with sperm in a lab and implanted in your uterus (in vitro fertilization). Egg freezing or oocyte cryopreservation is a method of fertility preservation where a woman’s eggs are harvested, frozen and stored. In this procedure eggs are extracted from the ovaries, which are stored and then preserved for future use. Women with certain medical conditions required to undergo chemotherapy, radiotherapy or surgery which could affect the functioning of the ovaries take egg freezing into consideration. Couples who plan to delay parenthood also opt for this medical procedure. Once the eggs are extracted, their maturity is assessed under a microscope, and those eggs that are mature are cryopreserved. Storing the eggs for longer duration does not appear to have negative effects. When one chooses to use their frozen eggs, they are thawed, fertilized with sperm in a lab, and implanted in the patient or a gestational carrier uterus.

Endometrial Receptivity Analysis (or Array)
It is a genetic test that uses a small sample of a woman’s endometrial tissue to evaluate whether or not the endometrial lining is prepared to accept an implanting embryo. ERA is a genetic test that evaluates the expression of genes to evaluate whether the endometrial lining is properly developed to accept an embryo. This technique helps evaluate the woman’s endometrial receptivity from a molecular perspective. ERA indicates the window of implantation (WOI), increasing your chances of successful embryo transfer. Endometrial Receptivity Analysis requires a sample of the uterine lining obtained at a very specific time in the cycle. An endometrium is receptive when it is ready for the embryo implantation. This occurs around days 19-21 in each menstrual cycle of a fertile woman. ERA helps reveal the patient’s personalized window to determine the best time during their cycle that the uterus is most receptive, allowing the embryo to stick and grow. This analysis can be completed before starting assisted fertility treatment, IVF.

Ovulation induction is the stimulation of ovulation by medication. If a woman is not ovulating by herself then ovulation induction may be required. The most common causes of failure to ovulate are stress, weight fluctuations and Polycystic Ovarian Syndrome (PCOS). Other causes may include disorders of the pituitary gland, thyroid gland and raised prolactin levels. In some cases failure of ovulation is due to the ovarian failure. This may occur following treatment for cancer or may be the start of the menopause - premature ovarian failure. It is usually used in the sense of stimulation of the development of ovarian follicles to reverse anovulation or oligoovulation, but can also be used in the sense of triggering oocyte release from relatively mature ovarian follicles. If a woman has an irregular menstrual cycle, monitoring with ultrasound scans (follicle tracking) and hormone assessments may help to identify the fertile time of the month and so improve the chances of natural conception. Before ovulation problems can be treated it is important to undertake certain tests to establish the cause.

Male Fertility Treatments

male fertility treatment

Micro TESE or Microsurgical Sperm Retrieval is the retrieval of sperm from the testicle. Advances in reproductive medicine over the last 10 years have allowed men who were previously considered absolutely sterile to father biological children. Those advances have come on two fronts. The first was the advent of In-Vitro Fertilization (IVF) with Intra-Cytoplasmic Sperm Injection (ICSI). It turns out that men who have no sperm in the ejaculate because of problems with sperm production, a condition called Non-Obstructive Azoospermia (NOA), actually may have small pockets of sperm production within the testicle. In fact, greater than 60% of men with NOA actually do produce small amounts of sperm inside the testicle that can be used with IVF/ICSI to create a baby. In this procedure, an incision is made in the scrotum through which both testicles can be seen. The doctor then conducts a thorough examination of several areas of the testicles to check for any abnormalities and in order to identify the presence of sperm. This procedure is usually conducted only if all other Surgical Sperm Retrieval (SSR) techniques have been unsuccessful.

Percutaneous Epididymal Sperm Aspiration (PESA)
PESA or Percutaneous Epididymal Sperm Aspiration is a Surgical Sperm Retrieval (SSR) procedure where sperm is obtained by gentle suction after a fine needle is inserted into the epididymis, above the testis. PESA is used as part of assisted reproductive treatments for infertility. It can be used for IVF, where the extracted sperm is mixed with the wife’s egg for fertilisation to occur, or it can be used for ICSI, where a single extracted sperm is injected directly into an egg to fertillise it.This procedure is commonly used for patients who have undergone a vasectomy. Percutaneous epididymal sperm aspiration (PESA) is a technique used to determine sperm counts in the event of a possible blockage of the vas deferens. It is an alternative to micro-epidydimal sperm aspiration (MESA), and aims to address the technical difficulty and cost of MESA. This procedure is usually conducted when the ejaculate has no sperm because of an injury, blockage or previous surgery. PESA is usually performed prior to starting an IVF cycle, and the extracted sperm is frozen and stored for use in conjunction with Intracytoplasmic Sperm Injection (ICSI) during the IVF cycle.

Some men do not have enough sperm in their ejaculate to succeed with IVF. Fortunately, with the use of ICSI, many of these men will still have the opportunity to proceed with IVF. As long as there are some sperm in the testicle, these sperm can usually be obtained and individually inserted into their partner’s (or donor’s) eggs with Intra Cytoplasmic Sperm Injection (ICSI). If your semen analysis shows that you do not have sperm within your ejaculate, there are different methods of surgically retrieving the sperm, which is sometimes referred to as Surgical Sperm Retrieval (SSR). Testicular Sperm Aspiration (TESA) and Testicular Sperm Extraction (TESE) are both methods of SSR where sperm is retrieved from the tissue in a man’s testis. TESA uses gentle suction through a small needle while TESE involves taking a larger tissue sample from an incision. Both procedures are minor day surgeries and should be done before beginning an IVF cycle.

Sperm banking or freezing is a method of preserving sperm cells, and is especially useful for men who want to delay parenthood until a later stage. The purpose of cryopreserving semen (sperm banking) is to help ensure the possibility of conception in the future. When choosing a sperm bank, it is important to find a facility that you believe will be in business for many years to come (we have been open since the 1980s) so that you can safely store your sperm long-term. It is also useful for men who plan to undergo certain types of medical treatments (chemotherapy and radiation for instance) that could impact their sperm quality. Sperm may also be frozen as a backup option during a couple’s fertility treatment. Semen is analysed after being collected through ejaculation or surgically assisted retrieval like TESA or TESE, before the sperm cells are frozen in a laboratory. During an Intrauterine Insemination (IUI) or In-Vitro Fertilisation (IVF) procedure, the frozen sperm samples are used.

There are a number of reasons explaining the need for donated sperm. These include: Low sperm count in the partner’s semen due to various reasons such as injury, vasectomy or other male infertility factors, cancer treatment, etc. An inherited disease, such as Haemophilia or Duchenne’s Muscular Dystrophy, putting the life of a resulting baby at risk Incompatible blood types, if the female partner is Rhesus (Rh) sensitised and the male partner is Rh positive, the pregnancy is potentially problematic. In the case of donor eggs, while chances of pregnancy are similar to that of conventional IVF, the donor’s age is a key factor that impacts success rates.

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